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Myelin oligodendrocyte glycoprotein (MOG) 35-55, yon eleman minè nan sistèm nève santral (CNS) myelin, konsidere kòm yon otoantigen sib nan paralezit miltip (MS). Peptid sa a, yon epitop iminodominan kle nan MOG, pwovoke fò repons selil T ak B, kontribiye nan devlopman ansefalomielit eksperimantal otoiminitè (EAE) nan wonjè yo. Peptid MOG 35-55 pwodui yon maladi newolojik ki refè-remit ki karakterize pa yon gwo demyelinasyon ki sanble ak plak, ki sanble ak patoloji yo obsève nan MS, sa ki fè li yon modèl enpòtan pou etidye maladi a ak mekanis iminolojik li yo.
Espesifikasyon
|
Sekans yon sèl lèt kòd |
MEVGWYRSPFSRVHLYRNGK |
|
Sekans twa lèt kòd |
Met-Glu-Val-Gly-Trp-Tyrp-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-Leu-Tyr-Arg-Asn-Gly-Lys |
|
Nimewo CAS |
149635-73-4 |
|
Fòmil molekilè |
C118H177N35O29S1 |
|
Pwa molekilè |
2581.99 |
|
Modifikasyon |
N/A |
|
Pite |
Zòn pik pa HPLC Pi gran pase oswa egal a 95% |
|
Fòm |
Liyofilize |
|
Long Depo |
- 20 degre oswa pi ba |
| Pou itilize rechèch sèlman. | |
Referans:
1. Bettelli, E., Pagany, M., Weiner, HL, Linington, C., Sobel, RA, & Kuchroo, VK (2003). Myelin oligodendrocyte glycoprotein-espesifik T selil reseptè sourit transjenik devlope espontane neriti optik otoiminitè. Journal of Experimental Medicine, 197 (9), 1073-1081.
2. Williams, JL, Kithcart, AP, Smith, KM, Shawler, T., Cox, GM, & Whitacre, CC (2011). Selil memwa espesifik pou myelin oligodendrocyte glycoprotein (MOG) gouvène transfè eksperimantal ansefalomielit otoiminitè. Journal of Neuroimmunology, 234 (1-2), 84-92.
Baj popilè: mog (35-55), sourit, rat, mog (35-55), sourit, rat founisè
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