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Calpain Inhibitor III (Z-Val-Phe-aldehyde), also known as MDL 28170, is a cell-permeable and selective inhibitor of calpain, a family of calcium-dependent cysteine proteases. Calpains are involved in various cellular processes, including cytoskeletal remodeling, cell migration, and apoptosis, making their inhibitors of interest for research and therapeutic development.
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Z-V-F-CHO |
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Z-Val-Phe-CHO |
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88191-84-8 |
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C22H26N2O4 |
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382.45 |
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C-terminal aldehyde(al), N-terminal carbobenzyloxy (Cbz) |
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Peak Area by HPLC Greater than or equal to 95% |
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- 20 degree or below |
1.Huang, Y., & Liu, Y. (2006). Inhibition of calpain activity protects neurons from ischemia-induced injury in rats. Neurobiology of Disease, 23(2), 415-423. 2. Erickson, J. C., & Hersh, L. B. (1997). MDL 28170 and its effects on cellular calcium homeostasis and proteolysis in human T-cells. The Journal of Immunology, 159(5), 2306-2312.
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